High molecular weight kininogen contributes to early mortality and kidney dysfunction in a mouse model of sickle cell disease

BACKGROUND: Sickle cell disease (SCD) is characterized by chronic hemolytic anemia, vaso-occlusive crises, chronic inflammation, and activation of coagulation. The clinical complications such as painful crisis, stroke, pulmonary hypertension, nephropathy and venous thromboembolism lead to cumulative...

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Publicado en:J Thromb Haemost
Autores principales: Sparkenbaugh, Erica M., Kasztan, Malgorzata, Henderson, Michael W., Ellsworth, Patrick, Davis, Parker Ross, Wilson, Kathryn J., Reeves, Brandi, Key, Nigel S., Strickland, Sidney, McCrae, Keith, Pollock, David M., Pawlinski, Rafal
Formato: Artigo
Lenguaje:Inglês
Publicado: 2020
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC8043232/
https://ncbi.nlm.nih.gov/pubmed/32573897
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jth.14972
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