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Protein kinase A controls the hexosamine pathway by tuning the feedback inhibition of GFAT-1
The hexosamine pathway (HP) is a key anabolic pathway whose product uridine 5’-diphospho-N-acetyl-D-glucosamine (UDP-GlcNAc) is an essential precursor for glycosylation processes in mammals. It modulates the ER stress response and HP activation extends lifespan in Caenorhabditis elegans. The highly...
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| Publicado en: | Nat Commun |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Nature Publishing Group UK
2021
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8041777/ https://ncbi.nlm.nih.gov/pubmed/33846315 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-22320-y |
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