Hexosamine Pathway Activation Improves Protein Homeostasis through the Integrated Stress Response

Activation of the hexosamine pathway (HP) through gain-of-function mutations in its rate-limiting enzyme glutamine fructose-6-phosphate amidotransferase (GFAT-1) ameliorates proteotoxicity and increases lifespan in Caenorhabditis elegans. Here, we investigate the role of the HP in mammalian protein...

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Publicado no:iScience
Main Authors: Horn, Moritz, Denzel, Sarah I., Srinivasan, Balaji, Allmeroth, Kira, Schiffer, Isabelle, Karthikaisamy, Vignesh, Miethe, Stephan, Breuer, Peter, Antebi, Adam, Denzel, Martin S.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7033349/
https://ncbi.nlm.nih.gov/pubmed/32086012
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2020.100887
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