Azide- and Alkyne-Bearing Metabolic Chemical Reporters of Glycosylation Show Structure-Dependent Feedback Inhibition of the Hexosamine Biosynthetic Pathway

Metabolic chemical reporters (MCRs) of protein glycosylation are analogues of natural monosaccharides that bear reactive groups, like azides and alkynes. When they are added to living cells and organisms, these small molecules are biosynthetically transformed into nucleotide donor sugars and then us...

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Veröffentlicht in:Chembiochem
Hauptverfasser: Walter, Lisa A., Batt, Anna R., Darabedian, Narek, Zaro, Balyn W., Pratt, Matthew R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6261355/
https://ncbi.nlm.nih.gov/pubmed/29979493
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cbic.201800280
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