IRS-2/Akt/GSK-3β/Nrf2 Pathway Contributes to the Protective Effects of Chikusetsu Saponin IVa against Lipotoxicity

Chronic hyperlipidemia leads to pancreatic β-cell apoptosis and dysfunction through inducing oxidative stress. Chikusetsu saponin IVa (CHS) showed antioxidant and antidiabetic properties in our previous studies; however, its protective effects against lipotoxicity-induced β-cell oxidative stress and...

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Detalhes bibliográficos
Publicado no:Oxid Med Cell Longev
Main Authors: Wang, Lei, Duan, Jialin, Jia, Na, Liu, Meiyou, Cao, Shanshan, Weng, Yan, Zhang, Wei, Cao, Jinyi, Li, Ruili, Cui, Jia, Wang, Jingwen
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi 2021
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8041533/
https://ncbi.nlm.nih.gov/pubmed/33884100
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2021/8832318
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