Brain exposure of the ATM inhibitor AZD1390 in humans—a positron emission tomography study

BACKGROUND: The protein kinase ataxia telangiectasia mutated (ATM) mediates cellular response to DNA damage induced by radiation. ATM inhibition decreases DNA damage repair in tumor cells and affects tumor growth. AZD1390 is a novel, highly potent, selective ATM inhibitor designed to cross the blood...

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Salvato in:
Dettagli Bibliografici
Pubblicato in:Neuro Oncol
Autori principali: Jucaite, Aurelija, Stenkrona, Per, Cselényi, Zsolt, De Vita, Serena, Buil-Bruna, Nuria, Varnäs, Katarina, Savage, Alicia, Varrone, Andrea, Johnström, Peter, Schou, Magnus, Davison, Chris, Sykes, Andy, Pilla Reddy, Venkatesh, Hoch, Matthias, Vazquez-Romero, Ana, Moein, Mohammad Mahdi, Halldin, Christer, Merchant, Melinda S, Pass, Martin, Farde, Lars
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2020
Soggetti:
Clinical Investigations
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8041329/
https://ncbi.nlm.nih.gov/pubmed/33123736
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa238
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