Brain exposure of the ATM inhibitor AZD1390 in humans—a positron emission tomography study

BACKGROUND: The protein kinase ataxia telangiectasia mutated (ATM) mediates cellular response to DNA damage induced by radiation. ATM inhibition decreases DNA damage repair in tumor cells and affects tumor growth. AZD1390 is a novel, highly potent, selective ATM inhibitor designed to cross the blood...

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Detalhes bibliográficos
Publicado no:Neuro Oncol
Main Authors: Jucaite, Aurelija, Stenkrona, Per, Cselényi, Zsolt, De Vita, Serena, Buil-Bruna, Nuria, Varnäs, Katarina, Savage, Alicia, Varrone, Andrea, Johnström, Peter, Schou, Magnus, Davison, Chris, Sykes, Andy, Pilla Reddy, Venkatesh, Hoch, Matthias, Vazquez-Romero, Ana, Moein, Mohammad Mahdi, Halldin, Christer, Merchant, Melinda S, Pass, Martin, Farde, Lars
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2020
Assuntos:
Clinical Investigations
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8041329/
https://ncbi.nlm.nih.gov/pubmed/33123736
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa238
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