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Brain exposure of the ATM inhibitor AZD1390 in humans—a positron emission tomography study
BACKGROUND: The protein kinase ataxia telangiectasia mutated (ATM) mediates cellular response to DNA damage induced by radiation. ATM inhibition decreases DNA damage repair in tumor cells and affects tumor growth. AZD1390 is a novel, highly potent, selective ATM inhibitor designed to cross the blood...
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| Udgivet i: | Neuro Oncol |
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| Main Authors: | , , , , , , , , , , , , , , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Oxford University Press
2020
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8041329/ https://ncbi.nlm.nih.gov/pubmed/33123736 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa238 |
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