PET imaging of [(11)C]PBR28 in Parkinson’s disease patients does not indicate increased binding to TSPO despite reduced dopamine transporter binding

PURPOSE: To examine the hypothesis that cerebral binding to the 18 kDa translocator protein (TSPO), a marker of microglia activation, is elevated in Parkinson’s disease (PD), and to assess the relationship between brain TSPO binding and dopaminergic pathology in PD. METHODS: The radioligand [(11)C]P...

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Bibliografiset tiedot
Julkaisussa:Eur J Nucl Med Mol Imaging
Päätekijät: Varnäs, Katarina, Cselényi, Zsolt, Jucaite, Aurelija, Halldin, Christer, Svenningsson, Per, Farde, Lars, Varrone, Andrea
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Springer Berlin Heidelberg 2018
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Original Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6333720/
https://ncbi.nlm.nih.gov/pubmed/30270409
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00259-018-4161-6
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