Modeling DNA trapping of anticancer therapeutic targets using missense mutations identifies dominant synthetic lethal interactions

Genetic screens can identify synthetic lethal (SL) interactions and uncover potential anticancer therapeutic targets. However, most SL screens have utilized knockout or knockdown approaches that do not accurately mimic chemical inhibition of a target protein. Here, we test whether missense mutations...

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Detalles Bibliográficos
Publicado en:Proc Natl Acad Sci U S A
Main Authors: Hamza, Akil, Amitzi, Leanne, Ma, Lina, Driessen, Maureen R. M., O'Neil, Nigel J., Hieter, Philip
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2021
Assuntos:
Biological Sciences
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC8040598/
https://ncbi.nlm.nih.gov/pubmed/33782138
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2100240118
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