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Cross-Species Complementation of Nonessential Yeast Genes Establishes Platforms for Testing Inhibitors of Human Proteins

Cross-species complementation can be used to generate humanized yeast, which is a valuable resource with which to model and study human biology. Humanized yeast can be used as an in vivo platform to screen for chemical inhibition of human protein drug targets. To this end, we report the systematic c...

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Publicat a:Genetics
Autors principals: Hamza, Akil, Driessen, Maureen R. M., Tammpere, Erik, O’Neil, Nigel J., Hieter, Philip
Format: Artigo
Idioma:Inglês
Publicat: Genetics Society of America 2020
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7054014/
https://ncbi.nlm.nih.gov/pubmed/31937519
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.119.302971
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