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Wild-type IDH1 inhibits the tumor growth through degrading HIF-α in renal cell carcinoma
The purpose of our study was to explore the effect and intrinsic mechanism of wild-type IDH1 and its substrate α-KG on renal cell carcinoma (RCC). IDH1 was observed lower expression in RCC cell lines. Phenotype experiment was carried out in the wild-type IDH1 and mutant IDH1(R132H) plasmid treated c...
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| Publicado no: | Int J Biol Sci |
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| Principais autores: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Ivyspring International Publisher
2021
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8040470/ https://ncbi.nlm.nih.gov/pubmed/33867843 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/ijbs.54401 |
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