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A Set of Highly Sensitive Sirtuin Fluorescence Probes for Screening Small-Molecular Sirtuin Defatty-Acylase Inhibitors

[Image: see text] Human sirtuins (SIRT1–7) regulate not only deacetylation but also deacylation of fatty acid-derived acyl moieties (defatty-acylation) at the ε-amino group of lysine residues. SIRT-subtype-specific defatty-acylase activity modulators are needed for detailed investigation of the biol...

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Bibliografiske detaljer
Udgivet i:ACS Med Chem Lett
Main Authors: Nakajima, Yuya, Kawaguchi, Mitsuyasu, Ieda, Naoya, Nakagawa, Hidehiko
Format: Artigo
Sprog:Inglês
Udgivet: American Chemical Society 2021
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8040038/
https://ncbi.nlm.nih.gov/pubmed/33859801
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.1c00010
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