Mitochondrial DNA alterations underlie an irreversible shift to aerobic glycolysis in fumarate hydratase-deficient renal cancer

Understanding the mechanisms of the Warburg shift to aerobic glycolysis is critical to defining the metabolic basis of cancer. Hereditary leiomyomatosis and renal cell carcinoma (HLRCC) is an aggressive cancer characterized by bi-allelic inactivation of the gene encoding the Krebs cycle enzyme fumar...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Sci Signal
Prif Awduron: Crooks, Daniel R., Maio, Nunziata, Lang, Martin, Ricketts, Christopher J., Vocke, Cathy D., Gurram, Sandeep, Turan, Sevilay, Kim, Yun-Young, Cawthon, G. Mariah, Sohelian, Ferri, De Val, Natalia, Pfeiffer, Ruth M., Jailwala, Parthav, Tandon, Mayank, Tran, Bao, Fan, Teresa W.-M., Lane, Andrew N., Ried, Thomas, Wangsa, Darawalee, Malayeri, Ashkan A., Merino, Maria J., Yang, Youfeng, Meier, Jordan L., Ball, Mark W., Rouault, Tracey A., Srinivasan, Ramaprasad, Linehan, W. Marston
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2021
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC8039187/
https://ncbi.nlm.nih.gov/pubmed/33402335
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.abc4436
Tagiau: Ychwanegu Tag
Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!

Eitemau Tebyg