Mitochondrial DNA alterations underlie an irreversible shift to aerobic glycolysis in fumarate hydratase-deficient renal cancer

Understanding the mechanisms of the Warburg shift to aerobic glycolysis is critical to defining the metabolic basis of cancer. Hereditary leiomyomatosis and renal cell carcinoma (HLRCC) is an aggressive cancer characterized by bi-allelic inactivation of the gene encoding the Krebs cycle enzyme fumar...

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Publicado no:Sci Signal
Main Authors: Crooks, Daniel R., Maio, Nunziata, Lang, Martin, Ricketts, Christopher J., Vocke, Cathy D., Gurram, Sandeep, Turan, Sevilay, Kim, Yun-Young, Cawthon, G. Mariah, Sohelian, Ferri, De Val, Natalia, Pfeiffer, Ruth M., Jailwala, Parthav, Tandon, Mayank, Tran, Bao, Fan, Teresa W.-M., Lane, Andrew N., Ried, Thomas, Wangsa, Darawalee, Malayeri, Ashkan A., Merino, Maria J., Yang, Youfeng, Meier, Jordan L., Ball, Mark W., Rouault, Tracey A., Srinivasan, Ramaprasad, Linehan, W. Marston
Formato: Artigo
Idioma:Inglês
Publicado em: 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8039187/
https://ncbi.nlm.nih.gov/pubmed/33402335
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.abc4436
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