CRISPR Screens in Synthetic Lethality and Combinatorial Therapies for Cancer

SIMPLE SUMMARY: The synthetic lethality (SL) clinical success of PARP inhibitors in homologous recombinant deficient tumors has established a new concept for cancer treatment. For decades, efforts have centered on identifying genetic interactions for determining essential tumoral genes, and more rec...

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Bibliographic Details
Published in:Cancers (Basel)
Main Authors: Castells-Roca, Laia, Tejero, Eudald, Rodríguez-Santiago, Benjamín, Surrallés, Jordi
Format: Artigo
Language:Inglês
Published: MDPI 2021
Subjects:
Review
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8037779/
https://ncbi.nlm.nih.gov/pubmed/33808217
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers13071591
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