Synthetic lethal screening reveals FGFR as one of the combinatorial targets to overcome resistance to Met-targeted therapy

Met is a receptor tyrosine kinase that promotes cancer progression. In addition, Met has been implicated in resistance of tumors to various targeted therapies such as EGFR inhibitors in lung cancers, and has been prioritized as a key molecular target for cancer therapy. However, the underlying mecha...

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Veröffentlicht in:Oncogene
Hauptverfasser: Kim, Bogyou, Wang, Shangzi, Lee, Ji Min, Jeong, Yunju, Ahn, TaeJin, Son, Dae-Soon, Park, Hye Won, Yoo, Hyeon-seok, Song, Yun-Jeong, Lee, Eunjin, Oh, Young Mi, Lee, Saet Byoul, Choi, Jaehyun, Murray, Joseph C, Zhou, Yan, Song, Paul H, Kim, Kyung-Ah, Weiner, Louis M
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2014
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4300291/
https://ncbi.nlm.nih.gov/pubmed/24662823
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2014.51
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