A New Anti-c-Met Antibody Selected by a Mechanism-Based Dual-Screening Method: Therapeutic Potential in Cancer

c-Met, the high affinity receptor for hepatocyte growth factor (HGF), is one of the most frequently activated tyrosine kinases in many human cancers and a target for cancer therapy. However, inhibitory targeting of c-Met with antibodies has proven difficult, because most antibodies have intrinsic ag...

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Bibliografiske detaljer
Main Authors: Oh, Young Mi, Song, Yun-Jeong, Lee, Saet Byoul, Jeong, Yunju, Kim, Bogyou, Kim, Geun Woong, Kim, Kyung Eun, Lee, Ji Min, Cho, Mi-Young, Choi, Jaehyun, Nam, Do-Hyun, Song, Paul H, Cheong, Kwang Ho, Kim, Kyung-Ah
Format: Artigo
Sprog:Inglês
Udgivet: Korea Society for Molecular and Cellular Biology 2012
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3887825/
https://ncbi.nlm.nih.gov/pubmed/23180291
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10059-012-0194-z
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