Synthetic lethal screening reveals FGFR as one of the combinatorial targets to overcome resistance to Met-targeted therapy

Met is a receptor tyrosine kinase that promotes cancer progression. In addition, Met has been implicated in resistance of tumors to various targeted therapies such as EGFR inhibitors in lung cancers, and has been prioritized as a key molecular target for cancer therapy. However, the underlying mecha...

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Publicado en:Oncogene
Autores principales: Kim, Bogyou, Wang, Shangzi, Lee, Ji Min, Jeong, Yunju, Ahn, TaeJin, Son, Dae-Soon, Park, Hye Won, Yoo, Hyeon-seok, Song, Yun-Jeong, Lee, Eunjin, Oh, Young Mi, Lee, Saet Byoul, Choi, Jaehyun, Murray, Joseph C, Zhou, Yan, Song, Paul H, Kim, Kyung-Ah, Weiner, Louis M
Formato: Artigo
Lenguaje:Inglês
Publicado: 2014
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4300291/
https://ncbi.nlm.nih.gov/pubmed/24662823
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2014.51
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