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Adaptability and Specificity: How do proteins balance opposing needs to achieve function?

Many proteins select from a small repertoire of 3-dimensional folds retained over evolutional timescales and recruited for different functions, with changes in local structure and sequence to enable specificity. Recent studies have revealed the evolutionary constraints on protein dynamics to achieve...

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Veröffentlicht in:Curr Opin Struct Biol
Hauptverfasser: Wingert, Bentley, Krieger, James, Li, Hongchun, Bahar, Ivet
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2020
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8036234/
https://ncbi.nlm.nih.gov/pubmed/33053463
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.sbi.2020.08.009
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