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Anti-CRISPR AcrIF9 functions by inducing the CRISPR–Cas complex to bind DNA non-specifically

Phages and other mobile genetic elements express anti-CRISPR proteins (Acrs) to protect their genomes from destruction by CRISPR–Cas systems. Acrs usually block the ability of CRISPR–Cas systems to bind or cleave their nucleic acid substrates. Here, we investigate an unusual Acr, AcrIF9, that induce...

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Publicat a:Nucleic Acids Res
Autors principals: Lu, Wang-Ting, Trost, Chantel N, Müller-Esparza, Hanna, Randau, Lennart, Davidson, Alan R
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2021
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8034650/
https://ncbi.nlm.nih.gov/pubmed/33660777
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkab092
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