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Anti-CRISPR AcrIF9 functions by inducing the CRISPR–Cas complex to bind DNA non-specifically

Phages and other mobile genetic elements express anti-CRISPR proteins (Acrs) to protect their genomes from destruction by CRISPR–Cas systems. Acrs usually block the ability of CRISPR–Cas systems to bind or cleave their nucleic acid substrates. Here, we investigate an unusual Acr, AcrIF9, that induce...

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Detalles Bibliográficos
Publicado en:Nucleic Acids Res
Main Authors: Lu, Wang-Ting, Trost, Chantel N, Müller-Esparza, Hanna, Randau, Lennart, Davidson, Alan R
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2021
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC8034650/
https://ncbi.nlm.nih.gov/pubmed/33660777
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkab092
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