mTORC1 promotes TOP mRNA translation through site-specific phosphorylation of LARP1

LARP1 is a key repressor of TOP mRNA translation. It binds the m(7)Gppp cap moiety and the adjacent 5′TOP motif of TOP mRNAs, thus impeding the assembly of the eIF4F complex on these transcripts. mTORC1 controls TOP mRNA translation via LARP1, but the details of the mechanism are unclear. Herein we...

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Pubblicato in:Nucleic Acids Res
Autori principali: Jia, Jian-Jun, Lahr, Roni M, Solgaard, Michael T, Moraes, Bruno J, Pointet, Roberta, Yang, An-Dao, Celucci, Giovanna, Graber, Tyson E, Hoang, Huy-Dung, Niklaus, Marius R, Pena, Izabella A, Hollensen, Anne K, Smith, Ewan M, Chaker-Margot, Malik, Anton, Leonie, Dajadian, Christopher, Livingstone, Mark, Hearnden, Jaclyn, Wang, Xu-Dong, Yu, Yonghao, Maier, Timm, Damgaard, Christian K, Berman, Andrea J, Alain, Tommy, Fonseca, Bruno D
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2021
Soggetti:
RNA and RNA-protein complexes
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8034618/
https://ncbi.nlm.nih.gov/pubmed/33398329
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkaa1239
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