The phospholipase D inhibitor FIPI potently blocks EGF-induced calcium signaling in human breast cancer cells

BACKGROUND: Phosphotyrosine kinase (PTK)-mediated phospholipase C-γ1 (PLC-γ1) signaling plays a crucial role in the release of the universal second messenger calcium from intracellular stores, which is mandatory for several cellular processes, including cell migration. However, PLC-γ1 could also be...

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Enregistré dans:
Détails bibliographiques
Publié dans:Cell Commun Signal
Auteurs principaux: Stricker, Helena M., Rommerswinkel, Nadine, Keil, Silvia, Gnoth, Sandina A., Niggemann, Bernd, Dittmar, Thomas
Format: Artigo
Langue:Inglês
Publié: BioMed Central 2021
Sujets:
Research
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC8034102/
https://ncbi.nlm.nih.gov/pubmed/33832505
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12964-021-00724-z
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