The phospholipase D inhibitor FIPI potently blocks EGF-induced calcium signaling in human breast cancer cells

BACKGROUND: Phosphotyrosine kinase (PTK)-mediated phospholipase C-γ1 (PLC-γ1) signaling plays a crucial role in the release of the universal second messenger calcium from intracellular stores, which is mandatory for several cellular processes, including cell migration. However, PLC-γ1 could also be...

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Detalhes bibliográficos
Publicado no:Cell Commun Signal
Main Authors: Stricker, Helena M., Rommerswinkel, Nadine, Keil, Silvia, Gnoth, Sandina A., Niggemann, Bernd, Dittmar, Thomas
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2021
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8034102/
https://ncbi.nlm.nih.gov/pubmed/33832505
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12964-021-00724-z
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