Hsp90 co-chaperones, FKBP52 and Aha1, promote tau pathogenesis in aged wild-type mice

The microtubule associated protein tau is an intrinsically disordered phosphoprotein that accumulates under pathological conditions leading to formation of neurofibrillary tangles, a hallmark of Alzheimer’s disease (AD). The mechanisms that initiate the accumulation of phospho-tau aggregates and fil...

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書目詳細資料
發表在:Acta Neuropathol Commun
Main Authors: Criado-Marrero, Marangelie, Gebru, Niat T., Blazier, Danielle M., Gould, Lauren A., Baker, Jeremy D., Beaulieu-Abdelahad, David, Blair, Laura J.
格式: Artigo
語言:Inglês
出版: BioMed Central 2021
主題:
Research
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC8033733/
https://ncbi.nlm.nih.gov/pubmed/33832539
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-021-01159-w
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