Hsp90 co-chaperones, FKBP52 and Aha1, promote tau pathogenesis in aged wild-type mice

The microtubule associated protein tau is an intrinsically disordered phosphoprotein that accumulates under pathological conditions leading to formation of neurofibrillary tangles, a hallmark of Alzheimer’s disease (AD). The mechanisms that initiate the accumulation of phospho-tau aggregates and fil...

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Bibliografiske detaljer
Udgivet i:Acta Neuropathol Commun
Main Authors: Criado-Marrero, Marangelie, Gebru, Niat T., Blazier, Danielle M., Gould, Lauren A., Baker, Jeremy D., Beaulieu-Abdelahad, David, Blair, Laura J.
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2021
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8033733/
https://ncbi.nlm.nih.gov/pubmed/33832539
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-021-01159-w
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