FKBP52 overexpression accelerates hippocampal-dependent memory impairments in a tau transgenic mouse model

Abnormal accumulation of hyperphosphorylated tau induces pathogenesis in neurodegenerative diseases, like Alzheimer’s disease. Molecular chaperones with peptidyl-prolyl cis/trans isomerase (PPIase) activity are known to regulate these processes. Previously, in vitro studies have shown that the 52 kD...

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Udgivet i:NPJ Aging Mech Dis
Main Authors: Criado-Marrero, Marangelie, Gebru, Niat T., Gould, Lauren A., Blazier, Danielle M., Vidal-Aguiar, Yamile, Smith, Taylor M., Abdelmaboud, Salma S., Shelton, Lindsey B., Wang, Xinming, Dahrendorff, Jan, Beaulieu-Abdelahad, David, Dickey, Chad A., Blair, Laura J.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2021
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8093247/
https://ncbi.nlm.nih.gov/pubmed/33941782
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41514-021-00062-x
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