A Multi-Omics Analysis of Metastatic Melanoma Identifies a Germinal Center-Like Tumor Microenvironment in HLA-DR-Positive Tumor Areas

The emergence of immune checkpoint inhibitors has dramatically changed the therapeutic landscape for patients with advanced melanoma. However, relatively low response rates and a high incidence of severe immune-related adverse events have prompted the search for predictive biomarkers. A positive pre...

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Detalhes bibliográficos
Publicado no:Front Oncol
Main Authors: Gadeyne, Laura, Van Herck, Yannick, Milli, Giorgia, Atak, Zeynep Kalender, Bolognesi, Maddalena Maria, Wouters, Jasper, Marcelis, Lukas, Minia, Angeliki, Pliaka, Vaia, Roznac, Jan, Alexopoulos, Leonidas G., Cattoretti, Giorgio, Bechter, Oliver, Oord, Joost Van Den, De Smet, Frederik, Antoranz, Asier, Bosisio, Francesca Maria
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2021
Assuntos:
Oncology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8029980/
https://ncbi.nlm.nih.gov/pubmed/33842341
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2021.636057
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