A Multi-Omics Analysis of Metastatic Melanoma Identifies a Germinal Center-Like Tumor Microenvironment in HLA-DR-Positive Tumor Areas

The emergence of immune checkpoint inhibitors has dramatically changed the therapeutic landscape for patients with advanced melanoma. However, relatively low response rates and a high incidence of severe immune-related adverse events have prompted the search for predictive biomarkers. A positive pre...

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Dettagli Bibliografici
Pubblicato in:Front Oncol
Autori principali: Gadeyne, Laura, Van Herck, Yannick, Milli, Giorgia, Atak, Zeynep Kalender, Bolognesi, Maddalena Maria, Wouters, Jasper, Marcelis, Lukas, Minia, Angeliki, Pliaka, Vaia, Roznac, Jan, Alexopoulos, Leonidas G., Cattoretti, Giorgio, Bechter, Oliver, Oord, Joost Van Den, De Smet, Frederik, Antoranz, Asier, Bosisio, Francesca Maria
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2021
Soggetti:
Oncology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8029980/
https://ncbi.nlm.nih.gov/pubmed/33842341
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2021.636057
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