Faulty splicing and cytoskeleton abnormalities in Huntington's disease

Huntington's disease (HD) is caused by a CAG‐repeat encoding a polyglutamine (polyQ) tract in the huntingtin protein. There is plenty of evidence of polyQ‐driven toxicity. However, CAG repeat RNA‐driven alteration of splicing has recently been proposed in analogy to CUG‐repeat diseases. Here we...

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Bibliografiske detaljer
Udgivet i:Brain Pathol
Main Authors: Fernández‐Nogales, Marta, Santos‐Galindo, María, Hernández, Ivó H., Cabrera, Jorge R., Lucas, José J.
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2016
Fag:
Mini‐symposium: Huntington's Disease
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8028924/
https://ncbi.nlm.nih.gov/pubmed/27529534
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bpa.12430
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