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Faulty splicing and cytoskeleton abnormalities in Huntington's disease
Huntington's disease (HD) is caused by a CAG‐repeat encoding a polyglutamine (polyQ) tract in the huntingtin protein. There is plenty of evidence of polyQ‐driven toxicity. However, CAG repeat RNA‐driven alteration of splicing has recently been proposed in analogy to CUG‐repeat diseases. Here we...
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| Publicado no: | Brain Pathol |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
John Wiley and Sons Inc.
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8028924/ https://ncbi.nlm.nih.gov/pubmed/27529534 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bpa.12430 |
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