The sterol regulatory element‐binding protein 2 is dysregulated by tau alterations in Alzheimer disease

Disturbed neuronal cholesterol homeostasis has been observed in Alzheimer disease (AD) and contributes to the pathogenesis of AD. As the master switch of cholesterol biosynthesis, the sterol regulatory element‐binding protein 2 (SREBP‐2) translocates to the nucleus after cleavage/activation, but its...

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Vydáno v:Brain Pathol
Hlavní autoři: Wang, Chunyu, Zhao, Fanpeng, Shen, Katie, Wang, Wenzhang, Siedlak, Sandra L., Lee, Hyoung‐gon, Phelix, Clyde F., Perry, George, Shen, Lu, Tang, Beisha, Yan, Riqiang, Zhu, Xiongwei
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2019
Témata:
Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8028548/
https://ncbi.nlm.nih.gov/pubmed/30515907
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bpa.12691
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