Posttranslational modifications of α-tubulin in alzheimer disease

BACKGROUND: In Alzheimer disease (AD), hyperphosphorylation of tau proteins results in microtubule destabilization and cytoskeletal abnormalities. Our prior ultra-morphometric studies documented a clear reduction in microtubules in pyramidal neurons in AD compared to controls, however, this reductio...

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Dades bibliogràfiques
Publicat a:Transl Neurodegener
Autors principals: Zhang, Fan, Su, Bo, Wang, Chunyu, Siedlak, Sandra L., Mondragon-Rodriguez, Siddhartha, Lee, Hyoung-gon, Wang, Xinglong, Perry, George, Zhu, Xiongwei
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2015
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4448339/
https://ncbi.nlm.nih.gov/pubmed/26029362
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40035-015-0030-4
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