The sterol regulatory element‐binding protein 2 is dysregulated by tau alterations in Alzheimer disease

Disturbed neuronal cholesterol homeostasis has been observed in Alzheimer disease (AD) and contributes to the pathogenesis of AD. As the master switch of cholesterol biosynthesis, the sterol regulatory element‐binding protein 2 (SREBP‐2) translocates to the nucleus after cleavage/activation, but its...

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Bibliographische Detailangaben
Veröffentlicht in:Brain Pathol
Hauptverfasser: Wang, Chunyu, Zhao, Fanpeng, Shen, Katie, Wang, Wenzhang, Siedlak, Sandra L., Lee, Hyoung‐gon, Phelix, Clyde F., Perry, George, Shen, Lu, Tang, Beisha, Yan, Riqiang, Zhu, Xiongwei
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2019
Schlagworte:
Research Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8028548/
https://ncbi.nlm.nih.gov/pubmed/30515907
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bpa.12691
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