Molecular mechanisms of APC/C release from spindle assembly checkpoint inhibition by APC/C SUMOylation

The anaphase-promoting complex/cyclosome (APC/C) is an E3 ubiquitin ligase that controls cell cycle transitions. Its regulation by the spindle assembly checkpoint (SAC) is coordinated with the attachment of sister chromatids to the mitotic spindle. APC/C SUMOylation on APC4 ensures timely anaphase o...

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Bibliographic Details
Published in:Cell Rep
Main Authors: Yatskevich, Stanislau, Kroonen, Jessie S., Alfieri, Claudio, Tischer, Thomas, Howes, Anna C., Clijsters, Linda, Yang, Jing, Zhang, Ziguo, Yan, Kaige, Vertegaal, Alfred C.O., Barford, David
Format: Artigo
Language:Inglês
Published: Cell Press 2021
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8028313/
https://ncbi.nlm.nih.gov/pubmed/33789095
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2021.108929
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