PP2A-activating drugs enhance FLT3 inhibitor efficacy through AKT inhibition-dependent GSK-3β-mediated c-Myc and Pim-1 proteasomal degradation

fms-like tyrosine like kinase 3 internal tandem duplication (FLT3-ITD) is present in acute myeloid leukemia (AML) in 30% of patients and is associated with short disease-free survival. FLT3 inhibitor efficacy is limited and transient but may be enhanced by multi-targeting of FLT3-ITD signaling pathw...

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Pubblicato in:Mol Cancer Ther
Autori principali: Scarpa, Mario, Singh, Prerna, Bailey, Christopher M., Lee, Jonelle K., Kapoor, Shivani, Lapidus, Rena G., Niyongere, Sandrine, Sangodkar, Jaya, Wang, Yin, Perrotti, Danilo, Narla, Goutham, Baer, Maria R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2021
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8027945/
https://ncbi.nlm.nih.gov/pubmed/33568357
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-20-0663
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