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Intrinsic and acquired resistance to CDK4/6 inhibitors and potential overcoming strategies
Abnormal activation of the cyclin-dependent kinases (CDKs), which result in aberrant cell proliferation, is one of the inherent characteristics of tumor. Thus targeting the activity of CDKs represents a promising tumor therapeutic strategy. Currently, the specific inhibitors that target CDK4 and CDK...
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| Publicado no: | Acta Pharmacol Sin |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Springer Singapore
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8027849/ https://ncbi.nlm.nih.gov/pubmed/32504067 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41401-020-0416-4 |
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