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New Strategies in Overcoming Acquired Resistance to EGFR Tyrosine Kinase Inhibitors in Lung Cancer

The management of non-small cell lung cancer (NSCLC) has been transformed by the observation that lung adenocarcinomas harboring mutations in EGFR are uniquely sensitive to EGFR tyrosine kinase inhibitors (TKIs). In these patients, acquired resistance to EGFR-TKI develops after a median of 10-14 mon...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Oxnard, Geoffrey R., Arcila, Maria E., Chmielecki, Juliann, Ladanyi, Marc, Miller, Vincent A., Pao, William
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2011
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3166976/
https://ncbi.nlm.nih.gov/pubmed/21775534
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-10-2571
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