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Mcl-1 inhibition overcomes intrinsic and acquired regorafenib resistance in colorectal cancer
Intrinsic and acquired resistance to targeted therapies is a significant clinical problem in cancer. We previously showed that resistance to regorafenib, a multi-kinase inhibitor for treating colorectal cancer (CRC) patients, can be caused by mutations in the tumor suppressor FBW7, which block degra...
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| Publicat a: | Theranostics |
|---|---|
| Autors principals: | , , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Ivyspring International Publisher
2020
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7381732/ https://ncbi.nlm.nih.gov/pubmed/32724460 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/thno.45363 |
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