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FBW7 mutations mediate resistance of colorectal cancer to targeted therapies by blocking Mcl-1 degradation

Colorectal cancer (CRC), the second leading cause of cancer-related deaths in the US, has been treated with targeted therapies. However, the mechanisms of differential responses and resistance of CRCs to targeted therapies are not well understood. In this study, we found that genetic alterations of...

詳細記述

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書誌詳細
出版年:Oncogene
主要な著者: Tong, Jingshan, Tan, Shuai, Zou, Fangdong, Yu, Jian, Zhang, Lin
フォーマット: Artigo
言語:Inglês
出版事項: 2016
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5226932/
https://ncbi.nlm.nih.gov/pubmed/27399335
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2016.247
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