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Rad9, a 53BP1 Ortholog of Budding Yeast, Is Insensitive to Spo11-Induced Double-Strand Breaks During Meiosis

Exogenous double-strand breaks (DSBs) induce a DNA damage response during mitosis as well as meiosis. The DNA damage response is mediated by a cascade involving Mec1/Tel1 (ATR/ATM) and Rad53 (Chk2) kinases. Meiotic cells are programmed to form DSBs for the initiation of meiotic recombination. In bud...

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Bibliographic Details
Published in:Front Cell Dev Biol
Main Authors: Usui, Takehiko, Shinohara, Akira
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2021
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8027355/
https://ncbi.nlm.nih.gov/pubmed/33842461
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fcell.2021.635383
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