IRE1α-XBP1 Affects the Mitochondrial Function of Aβ25–35-Treated SH-SY5Y Cells by Regulating Mitochondria-Associated Endoplasmic Reticulum Membranes

Background: Neurotoxicity induced by the amyloid beta (Aβ) peptide is one of the most important pathological mechanisms of Alzheimer's disease (AD). Activation of the adaptive IRE1α-XBP1 pathway contributes to the pathogenesis of AD, making it a potential target for AD therapeutics. However, th...

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Detalhes bibliográficos
Publicado no:Front Cell Neurosci
Main Authors: Chu, Bingcong, Li, Maoyu, Cao, Xi, Li, Rulong, Jin, Suqin, Yang, Hui, Xu, Linlin, Wang, Ping, Bi, Jianzhong
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2021
Assuntos:
Cellular Neuroscience
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8027129/
https://ncbi.nlm.nih.gov/pubmed/33841100
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fncel.2021.614556
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