IRE1α-XBP1 Affects the Mitochondrial Function of Aβ25–35-Treated SH-SY5Y Cells by Regulating Mitochondria-Associated Endoplasmic Reticulum Membranes

Background: Neurotoxicity induced by the amyloid beta (Aβ) peptide is one of the most important pathological mechanisms of Alzheimer's disease (AD). Activation of the adaptive IRE1α-XBP1 pathway contributes to the pathogenesis of AD, making it a potential target for AD therapeutics. However, th...

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Bibliographische Detailangaben
Veröffentlicht in:Front Cell Neurosci
Hauptverfasser: Chu, Bingcong, Li, Maoyu, Cao, Xi, Li, Rulong, Jin, Suqin, Yang, Hui, Xu, Linlin, Wang, Ping, Bi, Jianzhong
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2021
Schlagworte:
Cellular Neuroscience
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8027129/
https://ncbi.nlm.nih.gov/pubmed/33841100
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fncel.2021.614556
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