Posttranslational regulation of FOXA1 by Polycomb and BUB3/USP7 deubiquitin complex in prostate cancer

Forkhead box protein A1 (FOXA1) is essential for androgen-dependent prostate cancer (PCa) growth. However, how FOXA1 levels are regulated remains elusive and its therapeutic targeting proven challenging. Here, we report FOXA1 as a nonhistone substrate of enhancer of zeste homolog 2 (EZH2), which met...

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Detaylı Bibliyografya
Yayımlandı:Sci Adv
Asıl Yazarlar: Park, Su H., Fong, Ka-wing, Kim, Jung, Wang, Fang, Lu, Xiaodong, Lee, Yongik, Brea, Lourdes T., Wadosky, Kristine, Guo, Chunming, Abdulkadir, Sarki A., Crispino, John D., Fang, Deyu, Ntziachristos, Panagiotis, Liu, Xin, Li, Xue, Wan, Yong, Goodrich, David W., Zhao, Jonathan C., Yu, Jindan
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Association for the Advancement of Science 2021
Konular:
Research Articles
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC8026124/
https://ncbi.nlm.nih.gov/pubmed/33827814
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.abe2261
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