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USP15 negatively regulates Nrf2 through deubiquitination of Keap1
Nrf2 is a master regulator of the antioxidant response. Under basal conditions Nrf2 is polyubiquitinated by the Keap1-Cul3-E3 ligase and degraded by the 26S-proteasome. In response to Nrf2 inducers there is a switch in polyubiquitination from Nrf2 to Keap1. Currently, regulation of the Nrf2-Keap1 pa...
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| Glavni autori: | , , , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2013
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3732832/ https://ncbi.nlm.nih.gov/pubmed/23727018 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2013.04.022 |
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