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The structure of Prp2 bound to RNA and ADP-BeF(3) (−) reveals structural features important for RNA unwinding by DEAH-box ATPases
Noncoding intron sequences present in precursor mRNAs need to be removed prior to translation, and they are excised via the spliceosome, a multimegadalton molecular machine composed of numerous protein and RNA components. The DEAH-box ATPase Prp2 plays a crucial role during pre-mRNA splicing as it e...
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| Опубликовано в: : | Acta Crystallogr D Struct Biol |
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| Главные авторы: | , , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
International Union of Crystallography
2021
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8025883/ https://ncbi.nlm.nih.gov/pubmed/33825710 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S2059798321001194 |
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