Structural analysis of the intrinsically disordered splicing factor Spp2 and its binding to the DEAH-box ATPase Prp2

The spliceosome consists of five small RNAs and more than 100 proteins. Almost 50% of the human spliceosomal proteins were predicted to be intrinsically disordered or to contain disordered regions, among them the G-patch protein Spp2. The G-patch region of Spp2 binds to the DEAH-box ATPase Prp2, and...

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Publicat a:Proc Natl Acad Sci U S A
Autors principals: Hamann, Florian, Schmitt, Andreas, Favretto, Filippo, Hofele, Romina, Neumann, Piotr, Xiang, ShengQi, Urlaub, Henning, Zweckstetter, Markus, Ficner, Ralf
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2020
Matèries:
PNAS Plus
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7022188/
https://ncbi.nlm.nih.gov/pubmed/31974312
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1907960117
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