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Structural insights into the mechanism of the DEAH-box RNA helicase Prp43

The DEAH-box helicase Prp43 is a key player in pre-mRNA splicing as well as the maturation of rRNAs. The exact modus operandi of Prp43 and of all other spliceosomal DEAH-box RNA helicases is still elusive. Here, we report crystal structures of Prp43 complexes in different functional states and the a...

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Podrobná bibliografie
Vydáno v:eLife
Hlavní autoři: Tauchert, Marcel J, Fourmann, Jean-Baptiste, Lührmann, Reinhard, Ficner, Ralf
Médium: Artigo
Jazyk:Inglês
Vydáno: eLife Sciences Publications, Ltd 2017
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5262380/
https://ncbi.nlm.nih.gov/pubmed/28092261
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.21510
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