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Structural and functional analysis of the human spliceosomal DEAD-box helicase Prp28

The DEAD-box protein Prp28 is essential for pre-mRNA splicing as it plays a key role in the formation of an active spliceosome. Prp28 participates in the release of the U1 snRNP from the 5′-splice site during association of the U5·U4/U6 tri-snRNP, which is a crucial step in the transition from a pre...

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Main Authors: Möhlmann, Sina, Mathew, Rebecca, Neumann, Piotr, Schmitt, Andreas, Lührmann, Reinhard, Ficner, Ralf
格式: Artigo
語言:Inglês
出版: International Union of Crystallography 2014
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4051504/
https://ncbi.nlm.nih.gov/pubmed/24914973
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S1399004714006439
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