JMJD6 is a druggable oxygenase that regulates AR-V7 expression in prostate cancer

Endocrine resistance (EnR) in advanced prostate cancer (APC) is fatal. EnR can be mediated by androgen receptor splice variants (AR-SV), with AR-V7 arguably the most clinically important variant. In this study, we determined proteins key to generating AR-V7, validated our findings using clinical sam...

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Bibliografske podrobnosti
izdano v:Cancer Res
Main Authors: Paschalis, Alec, Welti, Jonathan, Neeb, Antje J., Yuan, Wei, Figueiredo, Ines, Pereira, Rita, Ferreira, Ana, Riisnaes, Ruth, Nava Rodrigues, Daniel, Jiménez-Vacas, Juan M., Kim, Soojin, Uo, Takuma, Di Micco, Patrizio, Tumber, Anthony, Islam, Saiful, Moesser, Marc A., Abboud, Martine, Kawamura, Akane, Gurel, Bora, Christova, Rossitza, Gil, Veronica S., Buroni, Lorenzo, Crespo, Mateus, Miranda, Susana, Lambros, Maryou B, Carreira, Suzanne, Tunariu, Nina, Alimonti, Andrea, Al-Lazikani, Bissan, Schofield, Christopher J., Plymate, Stephen R., Sharp, Adam, de Bono, Johann S.
Format: Artigo
Jezik:Inglês
Izdano: 2021
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC8025710/
https://ncbi.nlm.nih.gov/pubmed/33822745
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-20-1807
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