Shared immunogenic poly-epitope frameshift mutations in microsatellite unstable tumors

Microsatellite instability-high (MSI-H) tumors are characterized by high tumor mutation burden and responsiveness to checkpoint blockade. We identified tumor-specific frameshifts encoding multiple epitopes that originated from indel mutations shared among patients with MSI-H endometrial, colorectal...

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Publicat a:Cell
Autors principals: Roudko, Vladimir, Bozkus, Cansu Cimen, Orfanelli, Theofano, McClain, Christopher B., Carr, Caitlin, O’Donnell, Timothy, Chakraborty, Lauren, Samstein, Robert, Huang, Kuan-lin, Blank, Stephanie V., Greenbaum, Benjamin, Bhardwaj, Nina
Format: Artigo
Idioma:Inglês
Publicat: 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8025604/
https://ncbi.nlm.nih.gov/pubmed/33259803
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2020.11.004
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